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Approval for Work with Particularly Hazardous
Substances
As a matter of good practice, and to satisfy regulatory requirement,
particularly
hazardous substances require additional planning and considerations.
Laboratory workers planning to use a particularly hazardous substance
must first receive explicit written approval from their Principal
Investigator and/or Chemical Hygiene Officer, per the Departmental Chemical
Hygiene
Plan. The following steps must be taken:
1. Laboratory workers must complete a Particularly
Hazardous Substance Use Approval form. Information required
on the form includes:
- Identity, physical characteristics, and health hazards of the
substances involved
- Consideration of exposure controls such as fume hoods, glove
boxes and personal protective equipment
- Designation of an area (hood, glove box, portion of lab, entire
lab) specifically for experimental procedures with the substances
involved
- Plans for storage and secondary containment
- Procedures for safe removal of contaminated waste
- Decontamination procedures
2. The laboratory worker submits the form to the Chemical Hygiene
Officer and/or Principal Investigator and receives approval.
3. The area where the PHS will be used
is posted as a designated area. Signs for
this purpose are available through EHS or may be made by the department
or laboratory worker, as long as it includes the following information:
DANGER
DESIGNATED AREA
for select carcinogens, reproductive toxins and high acute toxicity
chemicals
AUTHORIZED PERSONNEL ONLY
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4. The laboratory worker proceeds with the experiment, following
the practices outlined in the Particularly Hazardous Substance
Use Approval form, as well as the appropriate work practices
included in the remainder of the Safe Work Practices and Procedures section
of this manual. All work is conducted within the Designated Area.
5. The laboratory worker decontaminates all equipment and
disposes of waste promptly, as outlined in the Particularly Hazardous
Substance Use Approval form.
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